Descriptions:Insulin-like growth factor I(IGF1)belongs to a family of insulin-like growth factors with the same structure as proinsulin.Mature mouse IGF-I has 94% and 99% amino acid sequence identity with human and rat IGF-I,respectively,and shows cross-species activity.
Applications:His tag
Tags:IGF-1
Descriptions:Galectin-8 (Gal-8) is a lectin family member and is one of the tandem repeat-type galectins containing two carbohydrate recognition domains (CRD) connected by a linker region in a single peptide chain. The CRD is responsible for β-galactoside binding, and the binding partners for galectin-8 have been identified, including CD44 and a subset of integrins. Galectin-8 and integrins form complexes, subsequently leading to phosphorylation of paxillin and focal adhesion kinase (FAK), which activates signal pathways including MAPK-ERK and PI3K-AKT pathways. Galectin-8 is constitutively presented in the Liver, kidney, cardiac muscle, lung, and brain. Galectin-8 serves as an immunosuppressive protective role against autoimmune CNS inflammation, regulating the balance of Th17 and Th1 polarization.
Tags:Galectin-8
Descriptions:Interleukin 17F (IL-17F) predicts a molecular mass of 30.1 kDa, is a cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. It is involved in the development of inflammation and host defense against infection by inducing the expression of genes that encode other proinflammatory cytokines, such as tumor necrosis factor, interleukin 1, interleukin 6 and some members of the colony-stimulating factor family.
Applications:His tag
Tags:IL-17F
Descriptions:Interleukin 12 p70 (IL-12 p70) is an interleukin which is major secreted from immune cells like dendritic cells, macrophages and neutrophils. IL-12 p70 is a 58.5 kDa protein containing 527 amino acid residues which is composed by two subunits (IL-12 p35 and IL-12 p40). IL-12 p70 induces the cytotoxic activity of immune cells like NK cells and T cells. IL-12 p70 binds its receptor (IL-12Rβ1 and IL-12Rβ2) that activates the Jak/STAT signaling pathway. IL-12 p70 also plays an important role in cancer model which inhibits the formation of new blood vessels through the production of IFN γ.
Tags:IL-12p70
Descriptions:Interleukin 12 (IL-12) is a pro-inflammatory cytokine with a molecular weight of 70 kDa composed of two subunits, IL-12 p35 (35 kDa) and IL-12 p40 (40 kDa). IL-12 p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form.
Tags:IL-12 p40
Descriptions:M-CSF is a potent hematopoietic factor produced by a variety of cells,including lymphocytes,monocytes,fibroblasts,endothelial cells,myoblasts and osteoblasts.
Applications:His tag
Tags:M-CSF
Descriptions:Fibroblast Growth Factors-19 (FGF-19) is a 24 kDa member of the fibroblast Growth Factors with 216 amino acid residues. FGF-19 is mainly secreted from cholangiocytes, ductal cells. FGF-19 involved cell proliferation, glucose and bile acid metabolism via FGFR4 pathway.
Tags:FGF-19
Descriptions:Interleukin 38 (IL-38) is a 16.87 kDa cytokine with 152 amino acid residues and a member of the interleukin-1 (IL-1) family. IL-38 is primarily secreted from basal epithelia of the skin and B cells of the tonsil, spleen, and thymus. It plays essential roles in inflammation and host defense by mediating NF-κB, AP1, and JNK signaling pathways when IL-38 binds to the receptors like IL1RAPL1 and IL-36R. In addition, IL-38 participates in down-regulating cell proliferation, migration, and up-regulating IL-6 and IL-10.
Tags:IL-38
Descriptions:C-X-C motif chemokine 6 (CXCL6) also named granulocyte chemotactic protein 2 (GCP-2), which is a chemokine of the intercrine alpha family. CXCL6 is a 8.3kDa protein containing 75 amino acid residues. CXCL6 has a significant role in resistance of gram-positive and gram-negative bacteria which is a chemotaxis for neutrophil granulocytes. CXCL6 has a role in in the process of carcinogenesis which affects proliferation and metastasis of OS cells by the interaction with CXCR1 /CXCR2.
Applications:His tag
Tags:CXCL6