| Product name | Mouse BMP-4 Protein, His tag |
| Sequence | Amino acid sequence derived from Mouse BMP4 (P21275) (Lys303-Arg408) was expressed. |
| Applications | His tag |
| Applications notes | Mouse |
| Activity | Testing in progress |
| Protein length | The recombinant Mouse BMP4 consists of 106 amino acids and predicts a molecular mass of 12.1 kDa. |
| Preparation method | E.coli |
| Purity | >98 % as determined by SDS-PAGE |
| Molecular Formula | 12.1KD |
| Alternative | bone morphogenetic protein 4, BMP-2B, DVR4, BMP4 |
| Formulation | Lyophilized from sterile PBS, pH 4.0. |
| Features & Benefits | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Molecular weight | 12.1KD |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Storage instructions | Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Bone morphogenetic protein 4 (BMP4) is a multifunctional ligand protein belonging to TGF β Family. BMP4 is expressed by endothelial cells (EC) in response to hypoxia and promotes proliferation of vascular smooth muscle cells (SMC). For example, it inhibits the proliferation of SMCs isolated from the proximal pulmonary artery while inducing the proliferation of SMCs isolated from the distal pulmonary artery. BMP4 seems to be a marker and driver of vascular calcification, especially in atherosclerosis. BMP4 induces angiogenesis, endothelial cell (EC) proliferation, and migration. BMP4 is differentially expressed in calcified atherosclerotic plaque, which is the junction between atherosclerotic vascular calcification and normal bone formation mechanism. BMP4 increases plaque formation, promotes oxidative stress, endothelial dysfunction and osteogenic differentiation through its proinflammatory and atherogenic effects. |
| Gene ID | 12159 |
| Alternative | bone morphogenetic protein 4, BMP-2B, DVR4, BMP4 |
| Accession | P21275 |
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1.The species of antibody reactivity should be the sample species that can be matched normally after Abbkine R&D experts have passed strict scientific verification. If your sample is not within the range of reactivity, in order to improve the efficiency and results of your experiment, it is not suggested to try other species. Otherwise, it may lead to sample mismatch and affect the effect of your experiment.
2.Please aliquot the antibody received as soon as possible and store it at -20℃, avoid repeated freezing and thawing, and use it within one year.
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